视网膜血管几何参数与肾脏损害的相关性研究进展

Research advances in correlation between geometric parameters of retinal vessels and renal damage

摘要: 肾脏疾病严重影响患者生活质量，其确诊依赖有创检查。视网膜血管和肾小球同属于微循环系统，视网膜血管参数的异常改变是微循环障碍的表现，可能提示肾脏损害。研究表明，视网膜血管直径、分形维数、弯曲度与提示肾脏损害的生物标志物有关，可成为预测和评估肾脏疾病进展的非侵入性指标，本文就视网膜血管几何参数与肾脏损害的相关性研究进行综述，为未来开发新的诊断工具和治疗方法提供依据。

Abstract: Renal diseases have a serious impact on the quality of life of patients and their definitive diagnosis relies on invasive tests. The retinal vasculature and glomeruli belong to the same microcirculatory system, and abnormal changes in retinal vascular parameters are indicative of microcirculatory disorders and may suggest renal damage. Studies have shown that retinal vessel diameter, fractal dimension, and tortuosity are associated with biomarkers suggestive of renal damage, and may be non-invasive indicators for predicting and assessing the progression of renal disease. This article provides a review of the correlation between geometric parameters of the retinal vasculature and renal damage to provide references for the future development of new diagnostic tools and therapeutic approaches.