Abstract: Objective The to observe the clinical analgesic effect of parecoxib sodium in scoliosis patients after spine orthopedic surgery. Methods Fifty scoliosis patients were randomly divided into parecoxib sodium group and control group. Patients in parecoxib sodium group were given 40 mg parecoxib sodium diluted into 2 ml saline by intravenous injection for 30 minutes before operation followed by 40 mg every 12 hours within 48 hours after operation. Patients in control group were given the same volume of saline for the same time.Patients in two groups were given parecoxib sodium through the patient-controlled infusion analgesia pump (PCIAP) after operation. Visual analog pain was scored and analgesia satisfaction rate of patients was assessed at 2, 6, 12, 24 and 48 h after operation. Pumping times of PCIAP, adverse reactions and blood coagulation were compared. Results The score of visual analog pain, the pumping times of PCIAP, and the dosage of parecoxib sodium were lower while the analgesia satisfaction rate was significantly higher in parecoxib sodium group than in control group at 6, 12, 24, 48 h after operation (P< 0.05). No significant difference was found in adverse reactions and blood coagulation between the two groups. Conclusion Parecoxib sodium, as an analgesic, can improve the analgesic effect in scoliosis patients after spine orthopedic surgery, thus reducing the use of other analgesics.