Abstract: Objective To study the clinical characteristics, diagnosis and treatment of calcaneus metastasis of breast carcinoma. Methods A case of breast carcinoma calcaneus metastasis was reported and retrospectively analyzed with its related literature reviewed. Results The patient was a 64-year-old female who underwent radical surgery of left infiltrating ductal carcinoma 10 years ago.She was found to have pulmonary metastatic carcinoma for more than 1 year and admitted to our hospital on May 19, 2011 due to severe left foot pain, mild left condyle edema, and mild limited activity.MRI showed abnormal signals from ankle bone and calcaneous of her left condyle joint.Calcaneous metastasis was diagnosed by radiology.Its symptoms improved significantly after radiotherapy, chemotherapy and expectant therapy. Conclusion Calcaneous metastasis of breast cancer is easy to be misdiagnosed as inflammation, trauma or gout.Its early clinical manifestations and radiology contribute to its early diagnosis.Local radiotherapy, chemotherapy and endocrine therapy are significantly effective against it.