Abstract: Objective To study the re-f ight of fghter pilots with nasopharyngeal carcinoma after radiotherapy． Methods Clinical data about a pilot with nasopharyngeal carcinoma (including diagnosis and treatment of nasopharyngeal carcinoma, follow-up and re-flight of the pilot) were retrospectively analyzed in order to establish its medical identification principles． Results The nasopharyngeal carcinoma disappeared in the pilot 8 months after radiotherapy without severe complications． Hypobaric chamber test showed that his eustachian tube, auditory and vestibular functions were normal． The fghter pilot was considered to be qualif ed to fy the double-seat fghter who adapted well to the fying for about 53 h． Flight-related tests showed that he could fy the singleseat fghter 20 months after radiotherapy． Conclusion The eff ciency of radiotherapy is good for early nasopharyngeal carcinoma in pilots with no severe complications, no recurrence and metastasis． Fighter pilots can be allowed to fy when fght-related tests show that their eustachian tube, auditory and vestibular functions are normal．