Abstract: Thermal texture maps technology is a new imaging technique which is also a major breakthrough in the field of optical imaging. This technology can detect the heat generated by cells and then analyze the intrinsic relationship and rules between body temperature distribution and diseases through collecting heat distribution information. To find out the relationship between disease and heat distribution, a suitable bio-heat transfer model is established and a new infrared thermograph analysis method is used to analyze the information about the heat sources on a human body in this paper. The model is used to process the temperature data in the possible pathological change region in a thermography, and two reference parameters:h for the depth of an inner heat source and q for the heat intensity of an inner heat source are chosen. These two parameters are very effective for the nature determination and location of tumors. Thermal texture maps technology is a radiation-free green method with rapid diagnostic procedure and accurate diagnosis result. The progresses of clinical research on the thermal texture maps technology are expounded and the advances in breast disease early diagnose are reviewed in this article.