5例原发性肝神经内分泌肿瘤的诊治

Diagnosis and treatment of patients with primary hepatic neuroendocrine tumor: An analysis of 5 cases

摘要: 目的探讨原发性肝神经内分泌肿瘤的诊疗方法。方法回顾性分析2013年1月- 2014年7月本院收治的5例原发性肝神经内分泌肿瘤的病例资料。结果 5例均经病理确诊，且未发现肝外病灶。男性3例(60%)，女性2例(40%)，发病年龄38～77岁，平均年龄61.2岁。4例确诊时即发现肝内转移，无手术机会。2例行单纯肝动脉栓塞化疗，2例化疗联合靶向治疗，1例化疗联合肝动脉栓塞。行化疗的3例病例中2例联合应用生长抑素类似物。最终2例失访，1例死亡，2例存活至今。结论原发性肝神经内分泌肿瘤早期诊断困难，可综合运用局部栓塞、化疗、靶向治疗及生长抑素类似物治疗，提高患者生存率。

Abstract: Objective To explore the diagnosis and treatment of primary hepatic neuroendocrine tumors (PHNET). Methods Clinical data about 5 PHNET patients from January 2013 to July 2014 in NO.1 department of oncology in the First Affiliate Hospital of Chinese PLA General Hospital were retrospective analyzed. Results Diagnosis of PHNET was confirmed immunohistochemically. No tumors were found out of liver. There were 3 males (60%) and 2 females (40%) with average age of 61.2 years (range from 38 to 77 years). Four patients were diagnosed with intrahepatic metastasis and lost the opportunity of operation. Of the 5 cases, 2 patients