Abstract: Objective To explore the clinical efficacy of¹²⁵I seed implantation or combination of¹²⁵I seed implantation and operation in treatment of patients with adenoid cystic carcinoma (ACC). Methods From January 2006 to July 2014, a total of 230 patients with ACC in our hospital were selected.Of the 230 patients, 17 cases had undergone brachytherapy by implantation of iodine 125 (¹²⁵I) seeds without resection, and 213 patients were implanted¹²⁵I seeds after resection.The efficacy and postoperative complications of patients with ACC were evaluated by clinical manifestation and imaging examination. Results All patients were followed up for 12-70 months and the median number of seeds implanted in one patient was 37.24.The clinical response rate (CR+PR) plus progression-free survival rate was 95.2% (219/230).No severe side effects were observed. Conclusion Brachytherapy of iodine 125 seed implantation combined with operation for patients with adenoid cystic carcinoma is quite an effective and safe treatment with minimal invasiveness.