Abstract: Objective To investigate the effect of different extent of resection on the prognosis of intracranial gliosarcoma. Methods Clinical data about 43 patients with gliosarcoma who were treated by surgical resection from January 2004 to January 2015 in our hospital were retrospectively analyzed, and the effect of different extent of resection on the prognosis of intracranial gliosarcoma were determined. Patients were divided into total resection group (n=33) and partial resection group (n=10). There were no significant differences in age, gender, MGMT and KPS score between two groups (P＞ 0.05). Results Twenty-four cases in total resection group were treated with adjuvant therapy which was performed in 5 patients of partial resection group. The median survival time of total resection group and partial resection group were 14 months and 9 months, respectively, and the survival rates of 6-month, 12-month of total resection group and partial resection group were 8.8%, 39.4% and 60%, 10% with significant differences (P＜ 0.05). Conclusion Gliosarcoma is a kind of highly malignant neoplasms with poor prognosis. Compared with partial resection, total resection of the tumor can prolong the survival time in patients with intracranial gliosarcoma.