Abstract: Hepatitis E is aglobal problem rather than only prevalent in developing countries which caused by hepatitis E virus (HEV) infection.Pregnant women are easy to be infected in hepatitis E outbreak which is the main reason for liver damage during pregnancy.Totally 81% of fulminant liver failure and 37% of acute hepatitis are caused by HEV infection in pregnant woman.HEV infection rate is higher during lategestation than early and middlegestation, and the mortality of HEV fulminant liver failure is higher during middle and lategestation (3-9 months).Illness severity and high mortality may be related to the change of hormone and immune response during pregnancy.Therefore, HEV infection during pregnancy should be paid close attention to.And, HEV infection rate and prognosis are different in different areas which probably associate with HEVgenotype, viral load and local prevalence.