Abstract: Objective To investigate the feasibility, safety and effectiveness of transcatheter arterial embolization (TAE) combined with laparoscopic ultrasound guided radiofrequency ablation (RFA) for the treatment of huge focal nodular hyperplasia (FNH)of the liver. Methods From April 2015 to June 2017, a total of 7 patients with huge FNH who were treated in the department of hepatobiliary surgery in Chinese PLA General Hospital were enrolled in this study. There were 3 males and 4 females with age ranged from 19 to 45 years old and tumor size of 10-13 cm. All patients were treated by TAE combined with laparoscopic ultrasound guided RFA and they were followed up for 6 months to 2 years. The perioperative condition and long-term outcome were observed. Results All the 7 patients had undergone TAE combined with laparoscopic ultrasound guided RFA successfully. No serious complications such as bleeding, bile leakage and intestinal fistula was observed. Computed tomography (CT) examination at 2-3 days after RFA revealed that the ablation region completely covered the lesion. There was no tumor recurrence or residual signs during the follow-up. Conclusion TAE combined with laparoscopic ultrasound guided RFA is safe and effective for the treatment of huge FNH of the liver.