Abstract: Prenatal testing includes prenatal screening and prenatal diagnosis such as serological screening, non-invasive prenatal testing (NIPT), fluorescence in situ hybridization (FISH), karyotype analysis, chromosome microarray analysis (CMA), next generation sequencing (NGS), etc. Different methods meet different clinical requirements and have different advantages as well as disadvantages. This study reviews some of these methods and provide evidences and advices to clinicians.