急性冠脉综合征患者血清胱抑素C水平与支架置入术后不良血管事件的相关性研究
Correlation between serum cystatin C level and main adverse cardiovascular events in patients with acute coronary syndrome after stent implantation
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摘要: 目的 研究急性冠脉综合征(ACS)患者血清胱抑素C(Cystatin C,Cys-C)水平与冠脉内支架置入术后主要不良心血管事件(MACE)发生的关系。 方法 回顾性分析156例冠脉内支架置入术治疗的ACS患者资料,将Cys-C水平按四分位法分为4组,比较各组术后6月内MACE发生率;按有无MACE分组,比较两组间血清Cys-C水平差异,Logistic回归分析筛选MACE危险因素。 结果 血清Cys-C水平,最高组与最低组相比MACE发生率明显增高(29.3%vs 10.2%,P<0.01),MACE组与无MACE组相比明显增高(1.37±0.15)mg/L,(1.11±0.18)mg/L,(P<0.01);Logistic回归分析表明,血清Cys-C水平是导致MACE发生的危险因素(OR 2.248,P<0.001)。 结论 ACS患者血清Cys-C水平与冠脉内支架置入术后短期MACE发生率呈正相关,且是术后短期MACE的危险因素。Abstract: Objective To study the correlation between serum cystatin-C（Cys-C） level and main adverse cardiovascular events（MACE）in patients with acute cardiovascular syndrome（ACS） after stent implantation. Methods Clinical data about 156 ACS patients who underwent stent implantation were retrospectively analyzed.The patients were divided into 4 groups according to their serum Cys-C level.Incidence of MACE was compared within 6 months after operation.The patients were then divided into MACE group and non-MACE group.Cys-C levels were compared between the two groups.Risk factors for MACE were analyzed by logistic regression analysis. Results The incidence of MACE and the Cys-C level were higher in MACE group than in non-MACE group29.3% vs 10.2%,（1.37±0.15）mg/L vs（1.11±0.18）mg/L,（P＜0.01）.Logistic regression analysis showed that the Cys-C level was one of the risk factors for MACE（OR=2.248,P＜0.001）. Conclusion Cys-C level in ACS patients is positively correlated with the incidence of MACE and is a risk factor for MACE after stent implantation.
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