陈东亚, 陈昭光, 杨凡, 千年松. 肿瘤免疫治疗相关炎性副反应及其治疗策略综述[J]. 解放军医学院学报, 2023, 44(3): 300-306. DOI: 10.3969/j.issn.2095-5227.2023.03.016
引用本文: 陈东亚, 陈昭光, 杨凡, 千年松. 肿瘤免疫治疗相关炎性副反应及其治疗策略综述[J]. 解放军医学院学报, 2023, 44(3): 300-306. DOI: 10.3969/j.issn.2095-5227.2023.03.016
CHEN Dongya, CHEN Zhaoguang, YANG Fan, QIAN Niansong. Review on inflammatory side effects of tumor immunotherapy and their therapeutic strategies[J]. ACADEMIC JOURNAL OF CHINESE PLA MEDICAL SCHOOL, 2023, 44(3): 300-306. DOI: 10.3969/j.issn.2095-5227.2023.03.016
Citation: CHEN Dongya, CHEN Zhaoguang, YANG Fan, QIAN Niansong. Review on inflammatory side effects of tumor immunotherapy and their therapeutic strategies[J]. ACADEMIC JOURNAL OF CHINESE PLA MEDICAL SCHOOL, 2023, 44(3): 300-306. DOI: 10.3969/j.issn.2095-5227.2023.03.016

肿瘤免疫治疗相关炎性副反应及其治疗策略综述

Review on inflammatory side effects of tumor immunotherapy and their therapeutic strategies

  • 摘要: 近年来,免疫治疗已经在临床得到了广泛应用,在不同瘤种治疗中都取得了显著效果。然而,我们也不应忽略免疫治疗作为双刃剑,亦能诱导各种炎性副反应,不仅减弱了免疫治疗疗效,导致免疫治疗的中止,也限制了免疫治疗与传统放化疗联合的开展。基于炎症在肿瘤发生、发展和治疗所有阶段的重要作用,炎症靶向治疗联合免疫治疗将不仅能减轻免疫治疗炎性副反应,且有可能提高新一代免疫疗法的疗效,为长期、多层次的肿瘤治疗提供新的可能性。本文主要介绍免疫治疗相关炎性副反应和相应机制的研究进展,探讨减轻炎性副反应的最新抗炎策略,从而为规避免疫治疗缺陷,最大程度发挥免疫治疗作用提供依据。

     

    Abstract: Immunotherapy has been widely used in clinical practice, and it has achieved remarkable effect on the treatment of tumors in different organs. However, as a double-edged sword, immunotherapy induces various inflammatory side effects, which not only weakens the efficacy of immunotherapy, leads to the suspension of immunotherapy, but also limits the development of immuno-therapy and the combination of traditional radiotherapy and chemotherapy. Therefore, based on the important role of inflammation in all stages of tumor genesis, development and treatment, targeted inflammatory therapy combined with immunotherapy will reduce inflammatory side effects of immunotherapy, and improve the efficacy of a new generation of immunotherapy, providing new possibilities for long-term, multi-level tumor treatments. In this article, we will introduce several major immunotherapy-related inflammatory side effects and the corresponding mechanisms to explore the latest anti-inflammatory strategies for reducing inflammatory side effects, so as to avoid immunotherapy defects and ultimately maximize the role of immunotherapy.

     

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