Effect of sleep apnea syndrome on some active cardiovascular substances

Objective:we investigated the change of some active vascular substances such as endothelium（ET）-1, angiotensin II（AngII）,Thromboxane B2 （TXB 2）, 6-keto-prostagladin （PGF）1α, calcium gene related protein（CGRP） in various severity of sleep apnea syndrome（SAS） and their relativity in order to futher understand the mechanism of how sleep apnea syndrome causes cardiovascular diseases and provide experimental evidences for the effective prevention and treatment of cardiovascular diseases in patients with SAS. Methods:37 patients primarily diagonesed as SAS, 32 men and 5 women, mean age（55.70±10.66） years old. They underwent polysomnography（PSG） test, apnea index（AI） and respiratory disorder index（RDI） were recorded. The patients were divided into normal, mild, medium and severe SAS group according to RDI. The blood ET-1, AngII, TXB 2,6-keto-PGF1α, CGRP were examined by means of radioimmune assay. Results:1. The blood ET-1, AngII and TXB 2 level was significantly higher in medium and severe SAS groups than that in normal and mild SAS groups, but there were no differences of blood 6-keto-PGF1α and CGRP level among all four groups. 2. correlation analysis showed that AI and RDI were significantly and positively correlated to ET-1, AngII and TXB 2 level, but had no correlation with 6-keto-PGF1α and CGRP level. Conclusion:some vascular substances such as ET-1, AngII and TXB 2 play an important role in the pathogenesis of cardiovascular diseases complicated with SAS.