Clinical study on venlafaxion hydrochloride in the treatment of slow-transit constipation

Objective: To evaluate the relationship between psychophysiologic disorders and slow-transit constipation （STC） and the efficacy of antidepressive agents in the treatment of STC. Methods: According to the relationship between psychophysiologic disorders and constipation, 114 patients with STC were divided into three groupswhich received venlafaxion hydrochloride（C group）, polyethylene glycol 4000（PEG4000）（B group） or both of them（A group） respectively.HAMA score,HAMD score, stool form and frequency and gastrointestinal gut transit time（GITT） were assessed before and at the end of treatment.（Results: Venlafaxion） hydrochloride and PEG4000 had no effect on GITT. Compared with pretreatment, HAMA and HAMD score decreased significantly at the end of treatment and their decrease in A and C group were greater, the improvement of stool form and stool frequency in A and B group were greater significantly than C group.Conclution: Psychophysiologic disorders are highly related to the occurrence and treatment of SCT. Combined antidepressive agents and laxatives may be effective in the treatment of SCT.