Evaluation of serum neuron-specific enolase and its half-life analysis in diagnosis and follow-up of small cell lung cancer

Objective: To evaluate the clinical value of detection of serum neuron-specific enolase（S-NSE） level and its half-life in differential diagnosis monitoring of chemotherapy and prediction of relapse of small cell lung cancer（SCLC）.Methods: The double mAb sandwich ELISA was used.Results: The sensitivity,specificity,and accuracy of the ELISA tests for detection of serum NSE were 85.0%,85.3%,88.7% respectively.The positive rates of serum NSE detected in limited stage（LS） and extensive stage（ES） patients with SCLC were 71.4%,92.3%;The patients whose serum NSE half-life were more than 20ds,the relapse would found from 47-183d since they had been found to be SCLC,the sensitivity of prediction of relapse by half-life of NSE was 80.0%.Conclusion: Detection of serum NSE level is of significance in differentiation between SCLC and NSCLC.The half-Life of serum NSE predicting the relapse of SCLC is better than the detection of serum NSE.