Discussion about duration of one session in bilirubin adsorption

Objective: To find out the proper duration of one session in bilirubin adsorption by studying the change of adsorption rate in a prolonged session.Methods: BR350 adsorption column was used on 11 cases of hyperbilirubinemia during each prolonged session.Blood samples were taken just before and after adsorption column at different time points.Results: 1.Serum bilirubin level after 1h,2h,3h of adsorption was significantly different from baseline respectively.2.There was a downtrend of adsorption rate during the treatment,but the lowest rate was nearly 40%.3. No severe side effects were found during treatment.Conclusion: 1.Bilirubin adsorption is an effective treatment of hyperbilirubinemia,plasma bilirubin concentration could decrease continuously during a session.2.There is a downtrend in adsorption rate that was still above 40% even after 3 hours which meant relatively good adsorption capability.Bilirubin adsorption with BR350 should be prolonged to not less than 3 hours.