Clinical significance of Hepatitis B virus large surface protein

Objective: To investigate the clinical significance of HBV large protein（LHBs）,we detected LHBs,HBV DNA,ALT and the hepatitis B viral markers（HBV M） in the serum of the patients infected with HBV.Methods: LHBs and HBV M were analyzed by ELISA;HBV-DNA was quantitatively detected using real-time PCR and ALT was assayed by auto biochemical analyzer.Results: （1）There was positive correlation between The OD value of LHBs and HBV DNA level.（2）The coincidence rate of LHBs and HBV DNA was obviously higher than that of HBeAg and HBV DNA（P＜0.05）.（3）the average value of ALT in LHBs positive patients was higher than that of LHBs negative patients.Conclusion: There is a perfect correlation between LHBs and HBV DNA,and LHBs is a reliable serological marker that can reflect the replication of HBV.The average value of ALT in LHBs positive patients was higher than that of LHBs negative patients.LHBs can partially reflect liver function.