Effect of controlled low central venous pressure on heart rate variability and hemodynamics of patients during hepatectomy

Objective To study the effect of controlled low central venous pressure on heart rate variability(HRV) and hemodynamics of patients during hepatectomy. Methods Twenty-nine ASAⅠ-Ⅱpatients underwent elective hepatectomy with controlled low central venous pressure technique under venous-inhalation general anesthesia.Their MBP,HR,BIS,HF,LF,and HF/LF ratio were recorded before anesthesia(T₀) and before deliberate hypotension(T₁),Immediately(T₂),at 5min(T₃),10min(T₄) and 15min(T₅) after CVP <5mmHg(1mmHg=0.133kPa),and immediately(T₆),at 5min(T₇),10min(T₈) and 15min(T₉) after CVP>5mmHg. Results The LF/HF ratio was higher at 10min after pressure restore than its basic value(P<0.05).However,no significant difference was found in the LF/HF ratio and its basic value at the other time points.The HF was lower at T₈ than at T₆(P<0.05).The LF/HF was higher at T₈-T₉ than at T₆(P<0.05).The HR was higher at T₄ than at T₀(P<0.05).The mean blood pressure was lower at T₁-T₉ than at T₀(P<0.05). Conclusion Venous-inhalation general anesthesia exerts no significant effect on the autonomic nervous system of patients during hepatectomy with controlled low central venous pressure technique under venous-inhalation general anesthesia and can maintain their normal sympathetic and parasympathetic tone,blood pressure and mean blood pressure.