Short-term curative effect of helical tomotherapy and conventional intensity- modulated radiotherapy for cervical carcinoma after operation

Objective To study the short-term curative effect of helical tomotherapy（HT） and conventional intensity-modulated radiotherapy（IMRT）for cervical carcinoma after operation. Methods Two hundred and twenty-eight patients with cervical carcinoma were divided into HT group（n=153） and IMRT group（n=75）.Lymph nodes in their pelvic drainage region and high risk drainage region,residual tumor and enlarged lymph nodes were irradiated 46-50 at the dose of 4Gy/23-28F,60Gy/25-28F and 6466Gy/25-28F,respectively.All patients received vagina after-loading brachytherapy at the dose of 8Gy on the surface of mucous membrane for 2-3 times.Response of bladder and rectum to radiotherapy were assessed following the radiation therapy oncology group（RTOG） and European organization for research on treatment of cancer（EPRTC） scoring criteria.The 1-3 year survival rate of the patients was analyzed after HT and IMRT. Results The grade 1 response of rectum and bladder to HT and IMRT was 28.76% and 42.67%（χ2=4.381,P=0.036）,and 10.46% and 17.33%（χ2=2.143,P=0.143）,respectively.No acute grade ≥ 2 response to HT and IMRT occurred in two groups.The 1-,2-and 3-year survival rate of patients after HT and IMRT was 94.22%,89.13%,85.21% and 93.86%,81.84%,71.11%,respectively（P=0.327）. Conclusion The acute response to HT is significantly lower than that to IMRT with no significant difference in the 1-3 year survival rate between the two groups.