Effect of different immune induction therapies on delayed kidney graft function recovery after transplantation

Objective To observe and compare the effect of induction therapy with methylprednisolone or basiliximab or thymoglobulin（ATG） on delayed kidney graft function（DGF） recovery after transplantation. Methods Clinical data about patients who underwent kidney transplantation in our center from January 2008 to December 2010 were retrospectively analyzed.DGF recovery of the patients after different induction therapies with tacrolimus or cyclosporine was analyzed. Results The total incidence of DGF following kidney transplantation was 21.62%.The incidence of DGF was 29.03%（9/31）,18.52%（5/27）,and 12.50%（2/16）,respectively,after induction therapy with methylprednisolone,basiliximab,and ATG（P＜0.05）.The time of kidney graft function recovery to normal was longer after induction therapy with methylprednisolone than after induction therapy with basiliximab and ATG（P＜0.05）. Conclusion Induction therapy with basiliximab and ATG can reduce the occurrence of DGF after kidney transplantation by inhibiting the subclinical acute rejection.