Nursing for patients with acute severe aplastic anemia treated with combined transplantation of haploid hematopoietic and umbilical cord mesenchymal stem cells

Objective To study the nursing methods of patients with severe aplastic anemia（SAA） after transplantation of haploid hematopoietic stem cells（haplo-HSC）. Methods Toxic reaction to antithymocyte globulin（ATG） in SAA patients was observed,transfusion speed and time of bone marrow stem cells and umbilical cord-derived mesenchymal stem cells（UC-MSC） were strictly controlled,and measures were taken to prevent graft versus host disease（GVHD）. Results No toxic reaction to ATG occurred in the 5 SAA patients.Bone marrow stem cells and haplo-HSC were successfully transfused into the patients with no hemolytic and blood transfusion reaction.Heterogeneous hematopoiesis was reconstructed in all patients.Skin rejection occurred in 3 patients（2 of them were complicated by liver rejection） and intestinal rejection occurred in 1 patient.The patients survived disease-free at the end of follow-up except 1 patient who was discharged 78 days after transplantation and lost contact. Conclusion Effective nursing for patients with GVHD after transplantation is the key to the success of transplantation.