Expression of Bmi-1 in esophageal squamous cell carcinoma tissue and its clinical significance
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SUN Yong-gang,
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TAN Xu-yun,
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YANG Xiao-mao,
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DU Xuan-feng,
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WANG Hui,
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MA Zhan-yuan,
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YUAN Li,
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ZENG Qing-hua,
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XU Qian,
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ZHAO Qian,
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ZHENG Qian
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Abstract
Objective To study the relation between Bmi-1 expression in esophageal squamous cell carcinoma(ESCC) tissue and biological behavior of ESCC. Methods Expressions of Bmi-1 protein and mRNA in 48 ESCC tissue samples were detected by immunohistochemical SP and RT-PCR, respectively. Results The expression levels of Bmi-1 protein and mRNA were significantly higher in ESCC tissue samples than in its adjacent tissue samples(P< 0.01). The over-expression of Bmi-1 protein was positively related with lymph node metastasis and differentiation of esophageal carcinoma(P< 0.05), but not with age, sex, and tumor size. Conclusion Bmi-1 is over-expressed in ESCC, which is closely related with the progress of ESCC, and can be used as a predicting marker for its biological behavior and prognosis.
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