Thrombelastography and coagulation parameters in chronic kidney disease patients and theirs clinical significance

Objective To observe the thrombelastography (TEG) and coagulation parameters in chronic kidney disease (CKD)patients. Methods Ninety CKD patients were divided into stage 1-2 CKD group, stage 3 CKD group, stage 4 CKD group, non-hemodialysis stage 5 CKD group and dialysis stage 5 CKD group.Their TEG and coagulation parameters were analyzed. Results The plasma levels of fibrinogen and its D-dimer were significantly higher whereas the plasma antithrombase Ⅲ level was significantly lower in non-hemodialysis stage 5 CKD group and dialysis stage 5 CKD group than in stage 1-2 CKD group and stage 3 CKD group (P＜ 0.05).TEG showed that the reaction time and K-time were significantly shorter in dialysis stage 5 CKD group than in stage 1-2 CKD group (P＜ 0.05).The maximal amplitude, G value and clotting index were significantly higher in non-hemodialysis stage 5 CKD group and stage 4 CKD group than in stage 1-2 CKD group and stage 3 CKD group (P＜ 0.05).Correlation analysis showed that the estimated GFR was negatively related with the plasma fibrinogen and its D-dimer levels, maximal amplitude, G value, clotting index and positively related with the plasma antithrombase Ⅲ level, reaction time and K-time (P＜ 0.05).Multivariate linear regression analysis showed that the clotting index was negatively related with the estimated GFR (P＜ 0.05). Conclusion Anemia, coagulation parameters and TEG contribute to the diagnosis of hypercoagulability in patients with CKD at stage 3-5.