Effect of decitabine in combination with modified CAG regimen in 4 cases of acute erythroleukemia

Objective To investigate the effect and side effect of decitabine in combination with Acla + Ara-C + G-CSF regimen on acute erythroleukemia. Methods Four patients with acute erythroleukemia were treated with decitabine in combination with CAG regimen. The effect and side effect of decitabine(20 mg/m², once a day for 5 days), G-CSF(300 μg, once a day from the day before chemotherapy to leukocyte recovery), Ara-C(10 mg/m², twice a day for 5 days), Acla(20 mg on days 1, 3, and 5) were observed. Results Of the 4 cases of acute erythroleukemia, 2 were completely recovered, 2 were partially recovered with mild adverse reactions during treatment. Conclusion The effect of decitabine in combination with CAG regimen on acute erythroleukemia is good with mild adverse reactions, and can thus be used an alternative regimen for acute erythroleukemia.