Primary bronchial and pulmonary amyloidosis:A clinical analysis of 9 cases

Objective To study the clinical manifestations,imaging features and treatment of primary bronchial and pulmonary amyloidosis. Methods Clinical data about 9 patients with primary bronchial and pulmonary amyloidosis admitted to our hospital from 1994 to 2012 were retrospectively analyzed with its related literature reviewed. Results The average age of the 9 patients（6 males and 3 females） with primary bronchial and pulmonary amyloidosis included in this study was 54 years.The main clinical manifestations in patients with pulmonary nodular parenchymal and tracheobronchial amyloidosis were cough,expectoration and hemoptysis.The clinical manifestations in patients with diffuse pulmonary interstitial amyloidosis were chest pain and hemoptysis.Chest CT showed nodular shadows in parenchymal amyloidosis patients,thickened tracheobronchial wall or calcification in tracheobronchial amyloidosis patients,and nodular and patching shadows in diffuse pulmonary interstitial parenchymal amyloidosis patients.The prognosis of pulmonary nodular parenchymal amyloidosis patients was usually good.Tracheobronchial amyloidosis usually exacerbated due to repeated infections and required bronchoscopic interventional therapy,anti-inflammation therapy,and cough-suppressing or phlegm-resolving therapy.The prognosis of diffuse pulmonary interstitial amyloidosis patients was usually poor. Conclusion Primary bronchial and pulmonary amyloidosis has no specific clinical and imaging manifestations,and is diagnosed according to its pathology.Expectant treatments such as anti-inflammation therapy can alleviate its symptoms.