Advances in tumor-associated gene thioredoxin domain containing protein 5

Thioredoxin domain containing protein 5（TXNDC5） is located on chromosome 6p24 and encodes a protein-disulfide isomerase containing 3 thioredoxin motifs which can compensate for a loss of PDI function in yeast.It has been shown that the expression level of TXNDC5 gene is higher in carcinoma tissues than in normal tissues.Following is a review of the advances in tumor-associated TXNDC5.