Effect of atorvastatin on multiple organ oxidative stress in aging rats

Objective To study the effect of atorvastatin on multiple organ oxidative stress, such as heart, liver and kidney, in aging rats. Methods Twenty months old rats were randomly divided into high statin dose (10 mg/kg · d) group, low statin dose (1 mg/kg · d) group, elderly control group and young control group. Their serum levels of SOD, MDA, CAT, NOS and LPF were measured. Results The serum levels of CAT, SOD and NOS were significantly higher whereas those of MDA and LPF were significantly lower in young control group and high statin dose group than in elderly control group and low statin dose group (P< 0.01). Conclusion Atorvastatin can inhibit the exaggerated multiple organ oxidative stress such as heart, liver and kidney, in aging rats.