Effect of renal insuffciency on clinical outcomes in heart failure patients after resynchronize therapy

Objective To study the effect of renal insuffciency on clinical outcomes in heart failure (HF) patients after resynchronize therapy. Methods Fifty-one consecutive HF patients who undewent resynchronize therapy in our hospital from 2007 to 2012 were retrospectively analyzed. The patients were divided into renal insuffciency group with its GFR< 60 ml/min and normal renal function or mild renal function impairment group with its GFR≥60 ml/min. Their clinical outcomes after resynchronize therapy were compared. Results The patients were followed up for an average period of 31.4 months. The all-cause mortality and the number of end point events were signifcant higher in renal insuffciency group than in normal renal function or mild renal function impairment group (P=0.02, P=0.001). Cox regression analysis revealed that the GFR, LVEDD, ACEI and ARB were closely related with the all-cause mortality and hospitalization rate in HF patients. Conclusion Renal insuffciency in HF patients increases their mortality and hospitalization rate after resynchronize therapy.