LIU Xiao-yan, XIN Shao-jie, CHEN Jing, XIAO Long, YANG Hao-zhen, TONG Jing-jing, HU Jin-hua. Significance of liver failure staging in predicting the prognosis of HBV-acute-on-chronic liver failure[J]. ACADEMIC JOURNAL OF CHINESE PLA MEDICAL SCHOOL, 2014, 35(6): 521-524,544. DOI: 10.3969/j.issn.2095-5227.2014.06.001
Citation: LIU Xiao-yan, XIN Shao-jie, CHEN Jing, XIAO Long, YANG Hao-zhen, TONG Jing-jing, HU Jin-hua. Significance of liver failure staging in predicting the prognosis of HBV-acute-on-chronic liver failure[J]. ACADEMIC JOURNAL OF CHINESE PLA MEDICAL SCHOOL, 2014, 35(6): 521-524,544. DOI: 10.3969/j.issn.2095-5227.2014.06.001

Significance of liver failure staging in predicting the prognosis of HBV-acute-on-chronic liver failure

  • Objective To study the clinical significance of liver failure staging in predicting the prognosis of HBV-acute-on-chronic liver failure (HBV-ACLF). Methods Four hundred and twenty-two HBV-ACLF patients admitted to our hospital from June 2009 to April 2011 were divided into early stage group (n=183), middle stage group (n=133) and end stage group (n=106). Their survival rates were analyzed. Results The mortality of the 3 groups at 4th week and 24th week was 18.58%, 24.81%, 79.25% and 33.33%, 45.11%, 84.91%, respectively, according to their prothrombin activity (PA) and complications at admission. The mortality of 199 end stage patients at 24th week was 88.44% according to the severity of HBV-ACLF in hospital stay time. The mortality at week 24 was significantly different in 5 groups divided according to the end-stage liver disease model. However, the mortality was not proportional to the end-stage liver disease model. Conclusion Liver failure staging can accurately predict the mortality in HBV-ACLF patients.
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