Short-term survival analysis of 195 glottis cancer patients treated by radiotherapy

Objective To evaluate the preliminary clinical results of 195 glottis cancer (GC) patients treated by three dimensional conformal radiotherapy (3D-CRT) or intensity modified radiotherapy (IMRT). Methods From July 2007 to April 2013 in Chinese PLA general hospital, 195 newly diagnosed GC patients were treated with radiotherapy, including 30 cases for radical treatment and 165 cases for adjuvant irradiation. The prescription dose was 64.5-70 Gy/33-35 F to the radical target, 50-60 Gy/30-33 F to the high risk target, and 44-54 Gy/22-33 F to the low risk target. Results The median follow up time was 36.7 months (range, 6 to 77 months). The local relapse-free survival (LRFS), regional relapse-free survival (RRFS), distant metastasis-free survival (MFS) and overall survival (OS) were 91.3%, 96.8%, 94.2% and 90.6% for 3 years, 88.2%, 96.8%, 91.7% and 83.5% for 5 years, respectively. The T stage and clinical stage could affect the 3-year LRFS, MFS and OS of patients. There was significant difference in 3-year RRFS and MFS between the patients at stage cN+ and cN-. Three year MFS in patients for one time resection were lower than those for more than once (χ²=8.810, P=0.003). Multivariate analysis showed that times of resection and cN± influenced the 3-year MFS (P=0.02) and age and T stage influenced the 3-year OS (P＜ 0.05). Conclusion The GC patients have good prognosis on the whole. Radiotherapy plays a very important role in comprehensive treatment for GC patients. Age and T stage can influence the 3-year OS and times of resection and cN± can influence the 3-year MFS. Salvage treatment is effective for the failure cases.