Genetics advances in primary aldosteronism

Primary aldosteronism （PA） is the most common and curable form of secondary hypertension which is primarily caused by either aldosterone-producing adenoma （APA） or by idiopathic hyperaldosteronism （IHA）. Only a tiny part of PA patients are familial hyperaldosteronism （FH）. Recent advances in genome technology have allowed researchers to unravel part of the genetic abnormalities of APA， IHA and FH. In this review， we mainly describe the genetic abnormalities associated with PA and may offer a new direction for diagnosis of PA and treatment in secondary hypertension.