Meta analysis of correlation between microvessel density for endoglin and lymph node metastasis and distant metastasis in colorectal cancer

Objective To investigate correlation between microvessel density (MVD) in endoglin (CD105) and lymph node metastasis, distant metastasis in the specimens of colorectal cancer. Methods Systematic searches of Wanfang, CNKI and cqvip databases meeting specifed search criteria were performed from January 2000 to October 2014 with “colorectal cancer, colon cancer, rectal cancer, endoglin, CD105” as key words, and the data meeting the selected standard were collected, then Meta-analysis was carried out by Revman 5.3. Results Twelve researches about the correlation of MVD for endoglin and lymph node metastasis were selected based on the standard. There were 741 patients, including 373 patients with lymph node metastasis and 368 patients without lymph node metastasis. Heterogeneity was found in these reports (χ²=136.86, P＜ 0.01, I²=92%). Random effects model was applied, and colorectal cancer tissues with or without lymph node metastasis were compared. The weighted mean difference (WMD) of MVD for endoglin was 9.89 (95% CI= 6.92 -12.85). The MVD for endoglin of colorectal cancer tissue with lymph node metastasis was signifcantly higher than that of colorectal cancer tissue without lymph node metastasis (Z=6.54, P＜ 0.05). Six reports about the correlation of MVD for endoglin and distant metastasis were selected based on the standard. There were 305 patients, including 79 patients with distant metastasis and 226 patients without distant metastasis. Heterogeneity was found in these researches(χ²=77.28, P＜ 0.01, I²=94%). Random effects model was applied, and colorectal cancer tissues with or without distant metastasis were compared. The WMD of MVD for endoglin was 7.9 (95% CI= 1.91-13.88). The MVD for endoglin of colorectal cancer tissue with distant metastasis was signifcantly higher than that of colorectal cancer tissue without distant metastasis (Z=2.59, P＜ 0.05). Conclusion In colorectal cancer patients, higher MVD for endoglin is observed in cancer tissues with lymph node metastasis and distant metastasis in colorectal cancer patients. The detection of MVD for endoglin in colorectal cancer has great signifcance in screening patients with high risk of metastasis.