Clinical characteristics of endocrine diseases with increased creatine kinase

Objective To analyze the different reasons and characters which cause the increase of creatine kinase (CK) in patients with endocrine disease． Methods Clinical data about 273 cases characterized as high CK from January 1, 2008 to January 1, 2014, including gender, age, diagnosis, CK level and relevant symptoms, were analyzed． Results The percentage of endocrine reasons which caused CK increase were listed below from high to low: diabetes without acute complication (33．7%) (diabetes with kidney disease accounting for 15%), hypokalemia related diseases (20．5%), function decrease in the frontier lobe of pituitary (16．5%), diabetes with acute complication (12．5%) (most patients had ketoacidosis), primary hypothyroidism (7．0%), hypoparathyroidism (5．9%), others (4%)． Patients had mild neural muscle symptoms accounting for 35．5%, and they showed higher CK level compared to the control group (P=0．000)． 97．1% of patients were cured without adverse outcomes． Conclusion For hospitalized patients with endocrine disease, the most common reasons which cause high CK in diabetes are diabetes kidney disease or diabetic ketoacidosis (DKA)． Patients without diabetes show higher rate in the presence of hypokalemia related diseases, anterior hypopituitarism and primary hypothyroidism, hypoparathyroidism． Most patients have no typical neural muscle symptoms and show good prognosis．