Distribution and antibiotic resistance of pathogens isolated from patients with chronic prostatitis

Objective To explore the species of pathogens in patients suffered from prostatitis and its antimicrobial susceptibility in vitro so as to offer a rational drug regimen in clinical practice． Methods All isolated pathogens were identified by Viteke-AMS-32 automatic microbiological analyzer and data statistical system． Results Three hundred and seventy-eight patients with chronic prostatitis were enrolled and succus prostaticus samples were cultured, totally 253 strains of microorganism were isolated with positive rate of 66．9%． Of the 253 strains of microorganism, 192 strains were gram-positive coccobacteria, accounting for 75．9%, including 86 strains of Staphylococcus aureus, accounting for 34．0%, 40 strains of Excrement intestines coccus (15．8%), and 66 coagulase-negative Staphylacocci, accounting for 26．1%, which mainly consisted of 37 strains of Staphylococcus epidermidis accounting for 14．6%． Other pathogenic bacteria included 13 strains of gram-positive Staphylococcus haemolyticus (5．1%), and 16 strains of other Staphylococcus (6．3%), respectively． Of the 61 strains of gram-negative bacteria (24．1%), it mainly consisted of Pseudomonas aeruginosa (25), Klebsiella pneumonia (17), and Escherichia coli (14)． The ratio of drug sensitivity of bacteria for vancomycin, teicoplanin, linezolid and levofloxacin were 100%, 96．8%, 100% and 82．1%, respectively． The gram-negative bacteria showed totally sensitive to vancomycin and teicoplanin, meanwhile the gram-positive bacteria showed totally sensitive to imipenem, but it presented different degree of resistance rate to oxacillin, ampicillin, cefoxitin, erythromycin, gentamycin, ceftazidime, and cefotaxime． Staphylococcus aureus showed more sensitive to levofloxacin, and excrement intestines coccus were sensitive to several commonly used antibiotics． Conclusion The pathogens causing chronic prostatitis infections in this research are gram-positive coccobacteria, coagulase-negative Staphylacocci, and gram-negative bacteria． Meanwhile some cases show mixed infections of pathogens mentioned above． The drug resistance rates of these pathogens demonstrate an increasing trend to commonly used antibiotics．