Multivariate analysis of survival-related factors of patients with pancreatic ductal adenocarcinoma after curative resection

Objective To identify multiple survival-related factors of patients with pancreatic ductal adenocarcinoma(PDAC)undergoing curative resection. Methods Clinical data about patients with resectable PDAC admitted to Chinese PLA General Hospital from January 2006 to July 2012 were collected retrospectively, and univariate and multivariate analysis were utilized to identify the prognostic value of clinicopathological indicators in resectable PDAC. Results Three hundred and seven patients were enrolled in this study.The median disease-free survival and overall survival was 10.1 months and 15.7 months, respectively.The disease-free survival rate and overall survival rate of 1-, 3-, 5-year was 33.2%, 2.9%, 0.3% and 64.5%, 8.1%, 1.6%, respectively.According to the results of univariate and Cox multivariate analysis, age was an independent prognostic value of disease-free survival(P＜0.05).Tumor size, the degree of tumor differentiation, T stage, lymph node status, preoperative CA125 level were found to be independent predictors for disease-free survival and also for overall survival. Conclusion Age, tumor size, the degree of tumor differentiation, T stage, lymph node status, preoperative CA125 level can provide useful information to estimate patients’prognosis after curative pancreatic resection due to PDAC.