Dark-adapted 3.0 oscillatory potentials in predicting ischemic central retinal vein occlusion

Objective To evaluate the predictive value of dark-adapted 3.0 oscillatory potentials in predicting the onset of ischemia in central retinal vein occlusion (CRVO). Methods Eighty eyes of 80 patients who had been diagnosed with CRVO in Yan'an People's Hospital from June 2010 to January 2015 were recruited. All patients had undergone ophthalmological examination, including visual acuity, intraocular pressure, fundus examination, ERG testing and fluorescein angiography. Patients were followed up for 2 to 9 months (mean 6 months), and they were divided into negative group and positive group according to whether they developed ischemic CRVO or not. Receiver operating characteristic (ROC) curve analysis was performed to determine the predictive value of amplitudes of oscillatory potentials (OPs) for ischemic CRVO. Results Certain wave and total amplitude of OPs could predict ischemic CRVO, and the sensitivity and specificity of 2nd wave of OPs (OP2) and total amplitude of OPs were the highest. Taking OP2=18.1μV as the cut-off point, the sensitivity was 96.7% and the specificity was 93.3% with the areas under the ROC curve of 0.981 (P< 0.001, 95% CI: 0.897-1.000). While, taking total amplitude of 64.9μV as the cut-off point, the sensitivity was 96.7% and the specificity was 90.0% with the areas under the ROC curve of 0.981 (P< 0.001, 95% CI: 0.903-1.000). Conclusion Decreased amplitudes of OPs are consistent with the degree of dysfunctional microcirculation in retina, which is a sensitive index in predicting ischemic CRVO.