ZOU Zhenyu, DU Xiaohui, LI Rong. Advances in adeno-associated virus antitumor therapy[J]. ACADEMIC JOURNAL OF CHINESE PLA MEDICAL SCHOOL, 2016, 37(7): 804-806,809. DOI: 10.3969/j.issn.2095-5227.2016.07.034
Citation: ZOU Zhenyu, DU Xiaohui, LI Rong. Advances in adeno-associated virus antitumor therapy[J]. ACADEMIC JOURNAL OF CHINESE PLA MEDICAL SCHOOL, 2016, 37(7): 804-806,809. DOI: 10.3969/j.issn.2095-5227.2016.07.034

Advances in adeno-associated virus antitumor therapy

  • Adeno-associated virus (AAV) is becoming the most promising vector for tumor gene therapy due to its superiority to other gene-carrying vectors, such as high transferring ability, low pathogenicity, low host immune response, and long-term gene expression. AAV has been successfully used to deliver and transfer a variety of therapeutic genes to cancer cells, including suicide genes, anti-angiogenic genes, and immune-related genes, to inhibit tumor initiation, growth and metastasis. Herein, we review the biological features and advances in research and application of AAV-mediated cancer gene therapy.
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