Advances in function of Raf kinase inhibitor protein and its relationship with tumor

Raf kinase inhibitor protein (RKIP), is a member of phosphatidylethanolamine-binding protein (PEBP) family. RKIP has been found to block the MAPK signal transduction pathway and suppress Raf-1-mediated MEK activation. RKIP not only inhibit tumor metastasis, but also increase the sensitivity of tumor cells to chemotherapeutic agents. It plays an important role in maintaining genome stability and cell migration. Therefore RKIP has been highlighted in cancer studies. We review its functions and the relationship with tumor in this article.