Clinical features of steroid-induced central serous chorioretinopathy after hematopoietic stem cells transplantation

Objective To discuss the manifestations of central serous chorioretinopathy (CSC) induced by systemic application of steroid after hematopoietic stem cells transplantation. Methods Medical records of 8 patients (11 eyes) who were diagnosed as CSC induced by corticosteroid following hematopoietic stem cells transplantation and examined by fundoscopy, fundus fluorescein angiography (FFA) and optical coherence tomography (OCT) were retrospectively analyzed. Results The best-corrected vision acuity (BCVA) in five eyes was 0.1-0.5, and 0.6-1.0 in six eyes on admission. Fundoscopy results showed yellow fibirinoid exudation in five eyes and bullous retinal detachment in four eyes. SD-OCT showed single sensory retinal detachment in seven eyes, and multifocal sensory retinal detachment in four eyes; retinal pigment epithelia detachment in six eyes, and five eyes with hypereflective spots below the sensory retina. Fluid and exudation below the sensory retina reduced after the decrease of corticosteroid dose, meanwhile the visual acuity improved. Conclusion CSC followed hematopoietic stem cells transplantation may damage the vision of patients. OCT may be helpful in early diagnosis. Stopping or reducing the doses of corticosteroids can improve the clinical symptoms.