Mitochondrial changes and energy metabolism dysfunction in mechanisms of ageingassociated osteoarthritis

LIU Ruoxi; YUAN Xueling; WANG Cheng; QUAN Qi; CHANG Biao; MENG Haoye; WANG Aiyuan; GUO Quanyi; LU Shibi; PENG Jiang

doi:10.3969/j.issn.2095-5227.2017.03.014

LIU Ruoxi, YUAN Xueling, WANG Cheng, QUAN Qi, CHANG Biao, MENG Haoye, WANG Aiyuan, GUO Quanyi, LU Shibi, PENG Jiang. Mitochondrial changes and energy metabolism dysfunction in mechanisms of ageingassociated osteoarthritis[J]. ACADEMIC JOURNAL OF CHINESE PLA MEDICAL SCHOOL, 2017, 38(3): 242-244. DOI: 10.3969/j.issn.2095-5227.2017.03.014

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Mitochondrial changes and energy metabolism dysfunction in mechanisms of ageingassociated osteoarthritis

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Ageing-associated changes are signifcant factors in the development of osteoarthritis (OA), and a number of studies have indicated potential mechanisms of ageing-associated OA. Our review aims at energy metabolism and changes in the extracellular matrix of articular catilage, which can cause the infammatory reaction, promote the catabolism and degeneration of joint tissue, and fnally resulte in OA.

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Mitochondrial changes and energy metabolism dysfunction in mechanisms of ageingassociated osteoarthritis

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