Relationship between the expression of CUE domain-containing 2 and lymph nodes metastasis in colorectal cancer

Objective To analyze the relationship between the expression of CUE domain-containing 2 (CUEDC2) and lymph nodes metastasis in colorectal cancer. Methods Clinical data and paraffinsections of 153 patients with colorectal cancer who underwent operation in Chinese PLA General Hospital from December 2015 to May 2016 were collected. The expression of CUEDC2 was analyzed by immunohistochemistry assay and univariate and multivariate analyses were carried out to investigate the association of the expression of CUEDC2 with lymph nodes metastasis. Results The immunohistochemical score of CUEDC2 in cases with lymph nodes metastasis of colorectal cancer was significantly higher than those without metastasis (7.41±1.46 vs 4.61±1.27, P< 0.05). Multivariate logistic regression analysis revealed that high immunohistochemical score of CUEDC2 was independent risk factor for lymph nodes metastasis in CRC patients (OR:4.777, 95% CI:2.827-8.071, P< 0.05). Conclusion High CUEDC2 immunohistochemical score (≥ 8) is correlated with lymph nodes metastasis in colorectal cancer and CUEDC2 probably promotes the metastasis.