Effects of M type phospholipase A2 receptors and its antibody on idiopathic membranous nephropathy

Membranous nephropathy is the main cause of nephrotic syndrome in adults, and the pathogenesis of idiopathic membranous nephropathy (IMN) is incompletely understood.IMN lacks sensitive and speci fic detection index, and its treatment and prognosis still remain controversial.M type phospholipase A2 receptors (PLA2R) is considered as a serological biomarker of IMN.Both PLA2R and its antibody (anti - PLA2R) are expressed in IMN patients, which have high speci ficity and sensitivity.Detection of PLA2R in kidney tissues and anti - PLA2R in serum have important signi ficance to the diagnosis, treatment and prognosis of IMN.This article reviews the latest research progress of PLA2R and its antibody in IMN, and summarizes its clinical value in IMN.