Relationship between serum uric acid level and long-term prognosis in patients with coronary heart disease

Objective To investigate the relationship between serum uric acid level and long-term prognosis in patients with coronary heart disease. Methods From January 2011 to September 2014, clinical data about 3 679 patients of coronary heart disease with an average age of (61.46±11.66) years in Chinese PLA General Hospital were retrospectively analyzed, and their blood pressure, heart rate, weight, height and blood biochemical tests results were recorded. The primary endpoint was defined as cardiovascular disease related death and the average follow-up period was (39.0±11.0) months. Patients were divided into four groups by uric acid levels, and then the relationship between serum uric acid level and long-term prognosis was analyzed. Results Multivariate cox-regression analysis showed that serum uric acid (HR=1.035; 95% CI: 1.018-1.052; P=0.038) and age (HR=1.070; 95% CI: 1.055-1.085; P< 0.001) were independent risk factors for cardiovascular disease related death in patients with coronary heart disease. While, statins(HR=0.419; 95% CI: 0.272-0.644; P< 0.001) and HDL-C(HR=0.321; 95% CI: 0.182-0.565; P< 0.001) were protective factors.Kaplan-Meier analysis showed that with the increase of serum uric acid level, the cumulative survival rate decreased significantly.There might be a threshold effect between uric acid and mortality in patients with coronary heart disease. Conclusion Uric acid is an independent risk factor for cardiovascular disease related death in patients with coronary heart disease. Thus, control of hyperuricemia is expected to reduce mortality in patients with coronary heart disease.Keywords: uric acid; coronary heart disease; mortality