Differential diagnostic value of texture analysis of posterior cingulate region on T1WI among the healthy,mild cognitive impairment and Alzheimer disease in older adults

Objective To compare the difference of the texture features of the posterior cingulate on T1WI among healthy elderly （HE）,the elderly patients with mild cognitive impairment （MCI） and the elderly patients with Alzheimer disease （AD）. Methods Theimaging data were obtained from Alzheimer's disease neuroimaging initiative （ADNI） database from January 2015 to August 2017.The texture analysis were performed based on T1WI among 168 HEs,233 patients with MCI and 101 patients with AD,and the texture parameters included Angular Second Moment （ASM）,Contrast,Correlation,Inverse Difference Moment （IDM）,and Entropy.The difference in texture parameter was compared between the three groups,and regression model was established by oridinal logistic regression analysis.Receiver operation characteristic （ROC） curve was used to evaluate the diagnostic efficacy. Results There were significant differences in the texture ASM,Contrast,IDM and Entropy among HE,MCI and AD (P_ASM=0.000,P_contrast=0.001,P_IDM=0.000 and P_entropy=0.000,respectively),while the texture Correlation presented no significant difference among the three goups (P_correlation=0.095).Oridinal Logistic regression analysis demonstrated that the texture IDM and Mini-mental State Examination score could be considered as the specific variables for the diagnosis of AD from HE and MCI.The area under the curve for equations established based on logistic regression was 0.894 （HE vs MCI-AD） and 0.995 （AD vs HE-MCI）. Conclusion The texture analysis of the posterior cingulate on T1WI could primarily be used to differentiate HE,MCI and AD.