Androgen-secreting ovarian sex cord stromal tumor:A clinical analysis of 10 cases and literature review

Objective To analyze and summarize the clinical features of androgen-secreting ovarian sex cord stromal tumors (SCST). Methods Clinical data about 10 female patients with androgen-secreting SCST who were confirmed by postsurgical pathology in the First Medical Center of Chinese PLA General Hospital in recent ten years were retrospectively analyzed. Results Ten female patientsaged 13 to 69 years old were enrolled in this study,with disease course of 1 to 6 years.Five patients firstly consulted in endocrinology department,and the other 5 cases were in gynecology department.Seven patients mainly presented with oligomenorrhea or secondary amenorrhea,and 3 patients with masculinization.Clinical features included hairiness (8/10),acne (3/10),voice change (5/10),clitorism (5/10),and trichomadesis (2/10).The preoperative testosterone level ranged from 3.90 nmol/L to 44.07 nmol/L,and it significantly reduced to 0-6.51 nmol/L at the second day after operation.The ovarian tumors were detected in eight patients by gynecological ultrasound,and in the other two patients by surgical exploration.Pathology results showed that all these ten ovarian sex cord stromal tumors were unilateral with diameter ranging from 0.7 cm to 8.0 cm.The tumors included Leydig cell tumors (2/10),stromal luteomas (3/10),nonspecific steroid cell tumors (2/10),sertoli-stromal cell tumors (2/10),and granulosa cell tumor (1/10). Conclusion For female patients with obvious hyperandrogenemia,the possibility of SCST should be considered.Such clinical presentation can be eliminated with successful surgery.