Expression of Aurora-A in cervical cancer and precancerous lesions and its correlation with HR-HPV infection

Objective To analyze the expression of Aurora-A in cervical cancer and precancerous lesions and its correlation with high risk-human papilloma virus (HR-HPV) infection. Methods A total of 110 cervical specimens were collected from the Shenzhen Second People's Hospital (the First Affiliated Hospital of Shenzhen University),with 22 cases had normal cervical tissues,22 cases had low-grade squamous intraepithelial lesions (LSIL),44 cases had high-grade squamous intraepithelial lesions (HSIL) and 22 cases had cervical cancer (CC).Aurora-A protein expression in various cervical specimens were detected by immunohistochemistry assay.The correlation of Aurora-A protein and HR-HPV with the degree of cervical lesions was analyzed. Results Compared to normal cervical tissue,Aurora-A was over-expressed in LSIL,HSIL and CC tissues (all P<0.05),and its positive rate increased with the degree of cervical lesions (r=0.486,P=0.032).There was also a positive correlation between the HR-HPV and the degree of cervical lesions (r=0.596,P=0.029).Aurora-A and HR-HPV were positively correlated (r=0.625,P=0.023). Conclusion Aurora-A overexpression may be related to the occurrence of cervical cancer,and may be used as a reference index for the diagnosis of squamous intraepithelial lesion and CC.