Relationship between ALDH2 polymorphisms and coronary stenosis severity in patients with premature coronary artery disease

  Background  Increasing evidences indicate that aldehyde dehydrogenase 2 (ALDH2) is a key enzyme of cytoprotection for the cardiovascular diseases, such as hypertension, heart failure, ischemia reperfusion injury, and so on. However, few studies have been conducted on the relationship between ALDH2 genotype polymorphism and premature coronary artery disease.

  Objective  To investigate the relationship between ALDH2 genotype polymorphism and coronary stenosis severity in patients with premature coronary artery disease.

  Methods  Totally 204 hospitalized patients (16-65 years) with premature coronary artery disease were assessed in Changping Hospital, and they were divided into wild genotype group (GG) and mutant genotypes group (GA or AA) according to their ALDH2 genotypes. The baseline data and Gensini score were measured. Results There were 130 cases in the ALDH2 wild genotype group, 61 cases in the mutant heterozygous genotype and 13 cases in the mutant homozygous genotype. The Gensini score (MdIQR:2210, 49 vs 268, 44, P =0.01) and the number of stents (Md IQR:10, 2 vs 20, 3, P=0.01) in the wild genotype group were lower than that in the mutant genotype group with statistically significant differences. Conclusion ALDH2 genotypes are closely related to coronary stenosis severity in patients with premature coronary artery disease, and coronary stenosis is more severe in patients with ALDH2 gene mutation.