Background Cervical cancer ranks the fourth most common cancers in women and greatly threatens women’s lives. The prevention and treatment of cervical cancer has been one of the major public health problems in China. Persistent infection with high-risk human papillomavirus (HR-HPV) causes cervical cancer and cervical squamous intraepithelial lesion (SIL).
Objective To investigate the relationship between HR-HPV types and SIL.
Methods With the support of Medical Big Data Center of Chinese PLA General Hospital, the data about female patients in Beijing who underwent HPV genotyping based on gene amplification and flow-through hybridization and gene chip and cervical biopsy in our hospital from January 2009 to June 2019 were screened out, with an interval of ≤ 180 days between the two examinations. The association between HPV genotyping and SIL was analyzed, and the association of age with HPV genotyping and SIL was also assessed, as well as the association of the number of HPV infection types with SIL.
Results A total of 280 female patients were eligible for this study, among whom 279 (99.64%) were diagnosed with SIL, 262 (93.57%) had HR-HPV, 125 patients (44.64%) had high-grade squamous intraepithelial lesion (HSIL), 154 patients (55%) had low-grade squamous intraepithelial lesion (LSIL). The female patients aged from 35 to 49 years had the highest incidence rate of HSIL/LSIL based on pathology. For the female patients with HSIL/LSIL, HPV16 was the most common HPV genotype, followed by HPV58, HPV52, HPV18 and HPV56. The frequency of single and multiple HPV infections was 62.86% and 30.71%, respectively, and the proportion of single/ multiple infections showed no significant different between HSIL and LSIL.
Conclusion The peak age with HSIL/LSIL is 35 to 49 years old. HPV16, HPV58 and HPV52 are the main high-risk HPV genotypes. Multiple high-risk HPV infections do not increase the risk of high-grade intraepithelial neoplasia.
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