Effects of hyperbaric oxygenations in treatment of noise induced hearing loss in China: A meta-analysis

DUAN Fujun; ZHANG Dan; XU Xianrong

doi:10.3969/j.issn.2095-5227.2021.07.016

Volume 42 Issue 7

Jul. 2021

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ACADEMIC JOURNAL OF CHINESE PLA MEDICAL SCHOOL > 2021 > 42(7): 761-766. > DOI: 10.3969/j.issn.2095-5227.2021.07.016

DUAN Fujun, ZHANG Dan, XU Xianrong. Effects of hyperbaric oxygenations in treatment of noise induced hearing loss in China: A meta-analysis[J]. ACADEMIC JOURNAL OF CHINESE PLA MEDICAL SCHOOL, 2021, 42(7): 761-766. DOI: 10.3969/j.issn.2095-5227.2021.07.016

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Effects of hyperbaric oxygenations in treatment of noise induced hearing loss in China: A meta-analysis

1.
Departmaent of Aviation Disease, Air Force Hospital of Southern Theater Command, PLA, Guangzhou 510602, Guangdong Province, China
2.
Vertigo Clinic/Research Center of Aerospace Medicine, Air Force Specialized Medical Center, PLA, Beijing 100142, China

Funds: Supported by the Foundation of Chinese Air Force Logistics Department (BKJ10J054); Standard Formulation Project of PLA Logistics Department (BKJ19B053)

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Corresponding author:
XU Xianrong. Email: xuxianrongkz@sina.com
Received Date: February 10, 2020
Available Online: October 18, 2021

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Abstract

Background Noise induced hearing loss (NIHL) is a slow progressive sensorineural deafness which can cause headache, dizziness, insomnia, hypertension, etc by the development of disease. Due to no effective treatment, it will seriously affect flight safety.
Objective To evaluate the effects of hyperbaric oxygenations (HBO) in treating NIHL, and provide more effective guidance for clinical treatment.
Methods Randomized controlled trials of HBO-treated NIHL (the experimental group was given HBO for intervention while the control group was not, both groups could be treated with other drugs or intervention) were retrieved from databases of CKNI, Wanfang, VIP and PubMed. The methodological quality assessment on included literature was processed by Jadad quality scoring method, and RevMan 5.3.0 was adopted to conduct Meta-analysis.
Results A total of 4 clinical randomized controlled trials met the inclusion criteria, including 284 patients (142 cases in experimental group and 142 cases in control group). Results of meta-analysis indicated that after HBO treatment, there was a statistically significant improvement of NIHL patients’ pure ton auditory threshold 0.5 kHz [MD=-5.95, 95%CI(-7.14 - -4.74), P＜0.01], 1 kHz [MD=-4.45, 95% CI (-5.34 - -3.56), P＜0.01], 2 kHz [MD=-4.58, 95% CI (-5.69 - -3.47), P＜0.01], 4 kHz [MD=-11.75, 95% CI (-13.73 - -9.77)]. No adverse reaction was reported.
Conclusion HBO treatment in NIHL patients can reduce the PTA threshold at 0.5 k, 1 k, 2 k, 4kHz without side effects. However, the PTA threshold reduction is need to be verified by high-quality clinical studies.
- hyperbaric oxygen,
- noise induced hearing loss,
- pure tone audiometry,
- meta-analysis,
- aircrew

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